Emerging Frontiers in CAR T-cell Therapy: Pioneering Immunotherapeutic Strategies in Oncology

Authors

  • Alka ZAde MUP's College of Pharmacy, Risod, India 444506

DOI:

https://doi.org/10.61920/jddb.v2i04.123

Keywords:

CAR T-cell therapy, Immunotherapy, Oncology, Immunotherapeutic strategies, Emerging frontiers

Abstract

CAR T-cell therapy stands at the forefront of immunotherapeutic innovations in oncology, revolutionizing cancer treatment paradigms. This review explores the latest advancements and frontiers in CAR T-cell therapy, elucidating its mechanisms, clinical applications, and challenges. We delve into novel engineering strategies for enhancing CAR T-cell efficacy and safety, including next-generation CAR designs, combinatorial approaches, and gene editing techniques. Furthermore, we discuss the expanding landscape of CAR T-cell therapy beyond hematological malignancies, encompassing solid tumors and viral infections. Insight into the intricate interplay between the tumor microenvironment and CAR T-cell function is provided, alongside emerging biomarkers for patient stratification and treatment monitoring. Finally, we address pivotal clinical trials, regulatory considerations, and future prospects, emphasizing the transformative potential of CAR T-cell therapy in reshaping the oncological treatment landscape

Downloads

Published

2024-04-30

How to Cite

ZAde, A. (2024). Emerging Frontiers in CAR T-cell Therapy: Pioneering Immunotherapeutic Strategies in Oncology. Journal of Drug Delivery and Biotherapeutics, 2(04), 58–65. https://doi.org/10.61920/jddb.v2i04.123